Pantokem/Pantokem IV

Pantokem Pantoprazole Na sesquihydrate. Pantokem IV Pantoprazole Na

Conditions where inhibition of gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, GERD, PUD, & Zollinger-Ellison syndrome.

Pantokem Erosive esophagitis Adult 40 mg once daily for up to 8 wk. Additional 8-wk course for patient who has not healed after 8 wk of treatment. PUD 40 mg once daily for 2-4 wk for duodenal ulcer, or 4-8 wk for benign gastric ulcer. H. pylori eradication Combined w/ 2 antibacterials in 1-wk triple therapy regimen: Pantoprazole 40 mg bid combined w/ clarithromycin 500 mg bid & either amoxicillin 1 g bid or metronidazole 400 mg bid. Pantokem IV 1 vial daily over 2-15 min. Reconstituted w/ 10 mL of physiological NaCl soln. May be administered directly & must be used w/in 24 hr of prep.

Should be taken on an empty stomach: Swallow whole 1 hr before a meal. Do not chew/crush.

Hypersensitivity.

Pregnancy & lactation. Pantokem Symptomatic response does not preclude gastric malignancy; not indicated for maintenance therapy. Use >16 wk. Not recommended in childn <12 yr. Pantokem IV Exclude malignancy in presence of any alarm symptoms (eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena) & when gastric ulcer is suspected or present, as treatment may alleviate/mask symptoms & delay diagnosis. Not recommended w/ co-administration of atazanavir. Slightly increased risk of GI infections caused by bacteria (eg, Salmonella & Campylobacter & C. difficile). Subacute cutaneous lupus erythematosus. Increased chromogranin A (CgA) level may interfere w/ investigations for neuroendocrine tumours; stop treatment for at least 5 days before CgA measurements to avoid interference. Monitor liver enzymes during therapy in patients w/ severe liver impairment. Discontinue treatment in case of rise in liver enzymes.

Headache, diarrhea, & skin rashes. Pruritus, dizziness, fatigue, constipation, nausea & vomiting, flatulence, abdominal pain, arthralgia & myalgia, urticaria, & dry mouth.

Pantokem IV May reduce absorption of drugs w/ gastric pH dependent bioavailability including azole antifungals eg, ketoconazole, itraconazole, posaconazole & other medicines eg, erlotinib. Substantial reduction in bioavailability & might impact efficacy of atazanavir & other HIV medications. Changes in INR during concomitant treatment w/ coumarin anticoagulants (eg, phenprocoumon or warfarin). Increased MTX levels in some patients.

Antacids, Antireflux Agents & Antiulcerants

A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Rx